Colorado rallied from a 48-21 third quarter deficit to make it a game, but nonetheless lost to USC for the 17th-straight time, falling 48-41 before a sellout crowd of 54.032. Shedeur Sanders threw for 371 yards and three touchdowns, while running for another, but it was not enough to keep up with USC quarterback Caleb Williams, who threw for six touchdowns and 403 yards. For the game, the Buffs actually out-gained the Trojans, with 564 total yards to 498 for USC, but the first half once again was the Buffs’ failing, with USC taking a 34-14 lead into the break.

Freshman wide receiver Omarion Miller, who had no receptions on the season coming into the game, collected seven passes for 196 yards and a touchdown. Jimmy Horn, Jr. contributed two touchdowns and 84 yards with his seven catches, while tight end Michael Harrison had six catches for 44 yards and a 21-yard touchdown. The Buff rushing “attack”, which had only 223 total yards in the first four games of the season, came alive with 193 yards on 45 carries. Running back Anthony Hankerson led the Buffs with 16 carries for 74 yards, posting a two-yard touchdown run.

“Wonderful game. They played their hearts out,” said Coach Prime. “I addressed the team and told them I love each of them, coaches included, because they were resilient. They did not give up and they had multiple, multiple opportunities to give up. They fought to the end. We sustained injuries, meaning the next man up came in and did their thing”.

Despite the second straight defeat, and despite having a defense which had given up 90 points in its last two games, Coach Prime was defiant. “If you can’t see what’s coming with CU football, you’ve lost your mind”, Sanders said. “You’re just a flat out hater. If you can’t see what’s going on and what’s going to transpire over the next several months. Something’s wrong with you.”